2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

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Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0204S2
    Pimobendan-d4
    		Inhibitor
    Pimobendan-d4 (UD-CG115-d4) is deuterium labeled Pimobendan (HY-B0204). Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
    Pimobendan-d<sub>4</sub>
  • HY-129474
    MP 518
    		Inhibitor
    MP 518 is a PDE inhibitor with antihypertensive properties. MP 518 can inhibit cAMP degradation, causing an increase in ICa, and can also antagonize β-adrenergic stimulation, exerting vasodilation.
    MP 518
  • HY-29268
    β-Carboline-1-carboxylic acid
    		Inhibitor
    β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL).
    β-Carboline-1-carboxylic acid
  • HY-B0809S1
    Theophylline-d3
    		Inhibitor
    Theophylline-d3 is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
    Theophylline-d<sub>3</sub>
  • HY-17464R
    Cilostazol (Standard)
    		Inhibitor
    Cilostazol (Standard) is the analytical standard of Cilostazol. This product is intended for research and analytical applications. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM.
    Cilostazol (Standard)
  • HY-120798
    4-Nitrophenyl phenylphosphonate
    		Substrate
    4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterase.
    4-Nitrophenyl phenylphosphonate
  • HY-B0204A
    Pimobendan hydrochloride
    		Inhibitor
    Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
    Pimobendan hydrochloride
  • HY-169804
    ENPP3 Inhibitor 1
    		Inhibitor
    ENPP3 Inhibitor 1 is a selective inhibitor of ENPP3, with IC50s of 0.15 µM (ENPP3) and 41.4 µM (ENPP1) respectively. ENPP3 Inhibitor 1 shows anti-tumor activities against breast cancer and cervical cancer.
    ENPP3 Inhibitor 1
  • HY-B1505R
    Acefylline (Standard)
    		Inhibitor
    Acefylline (Standard) is the analytical standard of Acefylline. This product is intended for research and analytical applications. Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research.
    Acefylline (Standard)
  • HY-W740060
    Dipyridamole Mono-O-β-D-glucuronide
    		Inhibitor
    Dipyridamole Mono-O-β-D-glucuronide (compound M4) is a derivative of the phosphodiesterase (PDE) and BCRP inhibitor Dipyridamole (HY-B0312) and is an O-glucuronide.
    Dipyridamole Mono-O-β-D-glucuronide
  • HY-14286R
    Levosimendan (Standard)
    		Inhibitor
    Levosimendan (Standard) is the analytical standard of Levosimendan. This product is intended for research and analytical applications. Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
    Levosimendan (Standard)
  • HY-109085R
    Difamilast (Standard)
    		Inhibitor
    Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD).
    Difamilast (Standard)
  • HY-14252R
    Milrinone (Standard)
    		Inhibitor
    Milrinone (Standard) is the analytical standard of Milrinone. This product is intended for research and analytical applications. Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.
    Milrinone (Standard)
  • HY-69317
    RS14203
    		Inhibitor
    RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis.
    RS14203
  • HY-114023
    BML-288
    		Inhibitor
    BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain.
    BML-288
  • HY-131383
    Propoxyphenyl Aildenafil
    		Inhibitor
    Propoxyphenyl Aildenafil is a Sildenafil analogue. Propoxyphenyl Aildenafil can be used for the research of enhancement of sexual function.
    Propoxyphenyl Aildenafil
  • HY-116850
    Oxagrelate
    Oxagrelate is a specific inhibitor of cyclic adenosine monophosphate phosphodiesterase and exhibits concentration-dependent inhibition of collagen- and ADP-induced platelet aggregation in vitro.
    Oxagrelate
  • HY-W171611
    PDE-IN-3
    		Inhibitor
    PDE-IN-3 (compound 23) is a phosphodiesterase (PDE) inhibitor with an IC50 of 260 μM.
    PDE-IN-3
  • HY-101312R
    Cilostamide (Standard)
    		Inhibitor
    Cilostamide (Standard) is the analytical standard of Cilostamide. This product is intended for research and analytical applications. Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
    Cilostamide (Standard)
  • HY-B1294R
    Amrinone (Standard)
    		Inhibitor
    Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent.
    Amrinone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

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